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Saarto T, Blomqvist C, VГѓ limГѓ ki M, et al Chemical castration induced by adjuvant cyclophosphamide, methotrexate, and fluorouracil chemotherapy causes rapid bone loss that is reduced by clodronate A randomized study in premenopausal breast cancer patients misoprostol 200 mcg tab ERОІ also eliminated the increased recruitment of H3K9me3 to p21 by E2 and ERО± Fig